Vitamin deficiencies: Rickets at bay

Vitamin D-dependent Rickets

1,25(0H)2D3 induces 25(OH)D3-24-hydroxylase (24-OHase) in cultured skin fibroblasts from normal subjects. We evaluated 24-OHase induction by 1,25(0H)2D3 in skin fibroblasts from 10 normal subjects and from four unrelated patients with hereditary resistance to 1,25(OH)2D or vitamin D-dependent rickets type II (DD II). Fibroblasts were preincubated with varying concentrations of 1,25(0H)2D3 for 1...

Vitamin deficiencies in chronic kidney disease

Familial Vitamin D-resistant Rickets

Rickets which is refractory to ordinary doses of vitamin D was first recognized when vitamin preparations of high potency became available (Albright, Butler and Bloomberg, 1937). As an isolated metabolic disorder it is commonly known as 'vitamin D-resistant rickets', also as 'phosphate diabetes' (Fanconi, 1936a, b) and phosphate losing(or renal tubular) rickets, type I (Dent, 1952). Whereas it ...

Images in pediatric endocrinology: vitamin D deficiency rickets and other nutritional deficiencies in a 12-month-old infant.

A girl of Indian ethnicity, born in Australia at term, presented at 12 months of age with irritability, failure to thrive, reluctance to weight bear and hypocalcemia. Her weight had decreased from the 25th to the 3rd percentile over 7 months. Her dietary intake had been predominantly breast and cow ’ s milk. Clinically, she had tender, widened wrists (Figure 1 ). Blood tests were consistent wit...

[Hereditary pseudo-vitamin D deficiency rickets].